Institute for Life Sciences, University of Southampton, Southampton, UK. Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. Institute for Life Sciences, University of Southampton, Southampton, UK; Tianjin Medical University - School of Pharmacy, Tianjin, China. Institute for Life Sciences, University of Southampton, Southampton, UK; Institute for Cancer Research, London, UK. Institute for Life Sciences, University of Southampton, Southampton, UK; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; Proteome Exploration Laboratory of the Beckman Institute, California Institute of Technology, Pasadena, CA, 91125, USA. Electronic address: S.D.Garbis@soton.ac.uk.